- Cell wall
- Pre-production -- bacitracin (subunit production & transport)
- Production -- vancomycin (elongation)
- Post-production -- beta-lactam (disrupt crosslinks); polymyxin B, collistin (detergent)
- Nucleic acid inhibitors
- NA metabolism -- trimethoprim, sulfadiazine/sulfonamide (antifolates); metronidazole, nitrofurantoin (anaerobic DNA inhibitor)
- DNA replication -- quinolones
- RNA synthesis -- rifampicin/rifamycin
- Protein synthesis
- 30S -- aminoglycosides (initiation); tetracycline (tRNA)
- 50S -- linezolid (initiation); chloramphenicol (peptidyl transferase); macrolides, clindamycin (transpeptidation/translocation)
- Elongation factor -- fusidic acid
- tRNA -- mupirocin (tRNA-ligase inhibitor)
Bacteriostatic -- erythromycin, clindamycin, SMX/TMP, tetracycline, chloramphenical (ECSTaTiC; credit -- USMLE Step 1 First Aid)
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